GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs2275426 | 1 | rs11211234 | chr1:46438787 | CCDC17 | chr1:46085717-46089729:- | 0.11 | 3.38 | 0.000746 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs11211234 | chr1:46438787 | MUTYH | chr1:45794915-45806142:- | 0.13 | 5.02 | 6.01E-7 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs11211241 | chr1:46452683 | CCDC163P | chr1:45960581-45965646:- | -0.4 | -11.78 | 3.42E-30 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs11211241 | chr1:46452683 | CCDC17 | chr1:46085717-46089729:- | 0.11 | 3.44 | 0.000607 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs11211241 | chr1:46452683 | MUTYH | chr1:45794915-45806142:- | 0.13 | 5 | 6.64E-7 | Body mass index |
| BRCA | cis | rs11216185 | 1 | rs11216186 | chr11:116784692 | SIDT2 | chr11:117049939-117068161:+ | 0.23 | 3.37 | 0.000771 | Infantile hypertrophic pyloric stenosis |
| BRCA | cis | rs11223996 | 1 | rs11223996 | chr11:134626887 | ACAD8 | chr11:134123434-134135744:+ | 0.22 | 4.45 | 9.67E-6 | Myopia (pathological) |
| BRCA | cis | rs11223996 | 1 | rs11223996 | chr11:134626887 | NCAPD3 | chr11:134022337-134094471:- | 0.17 | 4 | 6.85E-5 | Myopia (pathological) |
| BRCA | cis | rs11223996 | 1 | rs11223996 | chr11:134626887 | THYN1 | chr11:134118175-134123260:- | 0.16 | 3.8 | 0.000155 | Myopia (pathological) |
| BRCA | cis | rs11223996 | 1 | rs11223996 | chr11:134626887 | VPS26B | chr11:134094561-134117684:+ | 0.24 | 4.63 | 4.14E-6 | Myopia (pathological) |
| BRCA | cis | rs494003 | 1 | rs11227284 | chr11:65503224 | CTSW | chr11:65647284-65651212:+ | -0.21 | -7.17 | 1.43E-12 | Systemic lupus erythematosus |
| BRCA | cis | rs494003 | 1 | rs11227284 | chr11:65503224 | SNX32 | chr11:65601410-65621170:+ | 0.22 | 5.18 | 2.6E-7 | Systemic lupus erythematosus |
| BRCA | cis | rs494003 | 1 | rs11227288 | chr11:65516588 | CTSW | chr11:65647284-65651212:+ | -0.18 | -6.43 | 1.97E-10 | Systemic lupus erythematosus |
| BRCA | cis | rs494003 | 1 | rs11227288 | chr11:65516588 | RNASEH2C | chr11:65485146-65488409:- | -0.12 | -3.39 | 0.000714 | Systemic lupus erythematosus |
| BRCA | cis | rs494003 | 1 | rs11227288 | chr11:65516588 | SNX32 | chr11:65601410-65621170:+ | 0.21 | 5.11 | 3.87E-7 | Systemic lupus erythematosus |